Gene Mapping
- Identifies where genes are located on chromosomes so researchers can study their function and expression.
- Uses methods such as linkage analysis and physical mapping to place genes relative to each other or to physical DNA segments.
- Supports disease research, treatment development, and identification of genetic variations tied to traits or disease risk.
Definition
Section titled “Definition”Gene mapping is the process of identifying the location of a specific gene on a chromosome.
Explanation
Section titled “Explanation”Gene mapping locates specific genes within a chromosome, which enables researchers to study those genes’ function and expression and to understand their roles in an organism’s development and function. Mapping can reveal genes associated with particular traits or diseases and thereby inform research into targeted treatments or prevention strategies. Information from different mapping approaches can be combined to produce detailed maps of genetic material across chromosomes or entire genomes.
Examples
Section titled “Examples”Linkage analysis
Section titled “Linkage analysis”Linkage analysis analyzes the inheritance patterns of a specific trait or disease within a family. By comparing inheritance patterns of different genes in the family, researchers can determine which genes are likely to be located on the same chromosome and thereby identify the location of a specific gene on that chromosome.
Physical mapping
Section titled “Physical mapping”Physical mapping creates a detailed map of the genetic material on a chromosome. This is typically done by cutting the DNA into smaller pieces and then using a process called Southern blotting to identify the specific location of each piece. By combining information from multiple physical maps, researchers can create a detailed map of the entire genome.
Use cases
Section titled “Use cases”- Identifying the location of a gene associated with a particular disease so researchers can study the gene’s function and develop treatments that target that gene, potentially improving treatments and outcomes.
- Finding genetic variations associated with traits or diseases to develop targeted treatments or prevention strategies, which can be particularly beneficial for individuals at high genetic risk.
Related terms
Section titled “Related terms”- Linkage analysis
- Physical mapping
- Southern blotting
- Chromosome
- Genome
- Gene